Shufan "Vikki" Yin_Dr. Mehrara_Week 7

 Week 7 Summary

On Monday I attended a talk presented by Dr. Manuel Esteller on cancer epigenetics and its applications on cancer prediction and diagnosis. He introduced epigenetic hallmarks of cancers. For example, I learned that epigenetic loss of miA ALKBH3 generally leads to poor survival, while NSUN5 epigenetic loss leads to longer overall survival after cancer. Dr. Esteller also discussed his interesting findings on the world longest living person alive, Maria Branyas. The average biological age of her body was much younger than her actual chronological age. In the lab, I helped look into different mast cell knockout mice models to help plan for an experiment.

On Tuesday, I helped with the preparation steps for a flow cytometry experiment planned on Wednesday. We collected mice talk skin cells from wild type, PTEN ko, and PI3K ko mice. We stained for macrophages, T cells, LEC, and fibroblasts. The cells were fixed for flow cytometry the next day. On Wednesday, we used the equipment in MSKCC flow cytometry core facility to perform flow cytometry on the mice tail skin cells collected on Tuesday.

On Thursday, I did an HE staining of PDAC tissues and learned to mount glass covers on the slides. In the lab, I also helped with another project by looking into literature to search for peptide pools derived from human insulin to activate T cell in vitro.

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